TJ6

TJ6 is a pregnancy-associated protein isolated originally from murine placenta (Mandal and Beaman, 1995) and identified independently as RTF [Regeneration and tolerance factor]. TJ6 exists in soluble (TJ6s) and membrane-bound (TJ6m) forms (Mandal and Beaman, 1995; Nichols et al, 1994). Several isoforms have been described. TJ6 has been identified as a regulatory subunit of the vacuolar ATPase proton pump (see: ATP6V0A2).

In mice and humans, TJ6 protein is expressed on most of the placenta-associated mononuclear cells at all stages of pregnancy. The protein is expressed in murine thymus and also by an acute lymphocytic leukemia cell line (SB).

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Entry last modified: December 2008