TIGIT
[TIGIT(+), TIGIT(-)]
(approved gene symbol) [T-cell immunoreceptor with Ig and ITIM domains] The protein has been identified independently as WUCAM [Washington University Cell Adhesion Molecule], which is expressed on human follicular B helper T-cells (Boles et al, 2009).
TIGIT is an immunosuppressive protein identified by Yu et al (2009). The protein is expressed on regulatory T-cells, memory T-cells, and activated T-cells and is upregulated also in NK-cells. CD155, the Poliovirus receptor, which is expressed on dendritic cells, binds TIGIT with high affinity. Binding of CD155 to TIGIT on
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