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TIGIT

[TIGIT(+), TIGIT(-)]

(approved gene symbol) [T-cell immunoreceptor with Ig and ITIM domains] The protein has been identified independently as WUCAM [Washington University Cell Adhesion Molecule], which is expressed on human follicular B helper T-cells (Boles et al, 2009).

TIGIT is an immunosuppressive protein identified by Yu et al (2009). The protein is expressed on regulatory T-cells, memory T-cells, and activated T-cells and is upregulated also in NK-cells. CD155, the Poliovirus receptor, which is expressed on dendritic cells, binds TIGIT with high affinity. Binding of CD155 to TIGIT on ... ... ... ... ... Subscribe to continue reading! ... ...

 

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