Terms and Conditions of Use |
TERT(Æ4-13) |
GNCP-2 |
||
(approved gene symbol) [telomerase reverse transcriptase; also: hTERT (human); abbr. TRT in some publications] this enzyme, referred to also as telomere terminal transferase (Morin, 1989), is the catalytic subunit of Telomerase, a ribonucleoprotein complex containing the RNA component TERC [telomerase RNA component] and a number auf auxiliary associated proteins (for overview see: Cohen et al, 2007; Blackburn and Collins, 2011; Autexier and Lue, 2006; Hukezalie and Wong, 2013).
The holoenzyme is essential for the replication of chromosome termini in most eukaryotes and the maintenance of the repetitive sequences at chromosome ends known as telomeres. Shortening of telomere lengths below a critical value, initiates a DNA
...
...
...
...
... Subscribe to continue reading!
... ...
Content view restricted ! |