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StVOrth-2

This synthetic peptide, derived from human PEDF and corresponding to human PEDF(78-102) (VLLSPLSVATALSALSLGAEQRTES), has been shown to exhibit antitumor activity in an orthotopic model of human osteosarcoma, increasing the adhesion of osteosarcoma cells and reducing the invasiveness of these cells. The peptide also induces osteoblastic differentiation. The peptide does not inhibit angiogenesis in a tube formation assay (Ek et al, 2007).

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