spindle-shaped N-cadherin(+) CD45(-) osteoblastic cells |
SPINK1 |
Grim |
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Spinigerin (HVDKKVADKVLLLKQLRIMRLLTRL) is an antimicrobial peptide isolated from the fungus-growing termite Pseudacanthotermes spiniger (heterometabole insect, Isoptera) (Lamberty et al, 2001). It consists of 25 amino acids, is devoid of cysteines, and does not show any obvious sequence similarity to other peptides. Spinigerin is active against Gram-positive bacteria and Gram-negative bacteria and fungi and is present also in unchallenged termites. Spinigerin has no hemolytic activities against human erythrocytes.
Spinigerin shows structural similarities with cecropin A from Hyalophora cecropia, suggesting a similar mode of action on bacterial membranes (Landon et al, 2006).
For other proteins/peptides with functions in
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