SCA |
SCA-1 |
VGSLPG |
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[Sca-1(+), Sca-1(-), Sca-1(high), Sca-1(low)]
[stem cell antigen-1] This murine cell surface antigen is called also Ly6A/E or Ly6D (Lai et al, 1998). The gene encoding this antigen has been cloned independently as TAP [T-cell activating protein] by Reiser et al (1988), who referred to the encoded protein as Ly6.2 [lymphocyte antigen 6.2].
The antigen is expressed on immature hematopoietic progenitor cells (see also: hematopoiesis) and, together with other markers, defines hematopoietic stem cells (see also: KSL cells).
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