SP5032
This peptide, LLHISLLLIESRLE, is one of several endogenous peptides derived from proteins containing a conserved somatotropin domain and selected for inhibition of angiogenesis and lymphangiogenesis using in vitro proliferation, migration, adhesion and tube formation assays with blood and lymphatic endothelial cells (Lee et al, 2011). The peptide is derived from Chorionic somatomammotropin hormone-like 1
and corresponds to CSHL1(83-96) [Chorionic somatomammotropin hormone-like 1(83-96)]. The peptide potently inhibits proliferation of human umbilical vein endothelial cells
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