SP5001 |
SP5029 |
Small inducible cytokine A5 |
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This peptide, LMRKSQILISSWF, is one of several endogenous peptides derived from proteins containing a conserved somatotropin domain and selected for inhibition of angiogenesis and lymphangiogenesis using in vitro proliferation, migration, adhesion and tube formation assays with blood and lymphatic endothelial cells (Lee et al, 2011). The peptide is derived from MYO1A [brush border myosin-1] and corresponds to MYO1A(719-731) [brush border myosin-1(719-731)]. The peptide strongly inhibits the proliferation of microvascular endothelial cells, is active against these cells in an apoptosis assay
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