SNTF |
SNTVTCGQYVTLYCSTSGNYV |
camptodactyly-arthropathy-coxa vara-pericarditis |
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This targeting peptide (Ser-Asn-Thr-Arg-Val-Ala-Pro) has been isolated bycombinatorial peptide library screening in vivo on a human prostate cancer xenograft that is androgen-independent and induces a robust osteoblastic reaction in bone-like matrix and soft tissue. The peptide is enriched in the tumors, targets the cell surface of androgen-independent prostate cancer cells in vitro, and in vivo homes to prostate cancer that do not express androgen receptor. GRP78 [glucose-regulated protein-78] has been identified as a receptor for this peptide (Mandelin et al, 2015).
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