S1PR4

[Sphingosine-1-phosphate receptor 4] also: S1P4 [S1P receptor 4]. The receptor, cloned by Gräler et al (1998) from a dendritic cell library, is known also as EDG6 [Endothelial differentiation G-protein-coupled receptor 6]. EDG6 is expressed specifically in fetal and adult lymphoid and hematopoietic tissue as well as in lung. Van Brocklyn et al (2000) have shown that S1PR4 is a high affinity receptor for Sphingosine-1-phosphate, which also binds to S1PR1 and S1PR2.

S1PR4 has been shown to be expressed mostly in a variety of immune cells such as B-cells. dendritic cells, ... ... ... ...
 
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Entry last modified: March 2017