RH II/Gu |
rhinophrynin-33 |
TACTILE |
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Rhinocerosin (72 amino acids) has been purified from larvae of the coconut rhinoceros beetle, Oryctes rhinoceros immunized with Escherichia coli. The protein does not contain cysteine residues and is rich in glycine (11.1 %) and proline (11.1 %). Rhinocerosin has 77.8 % sequence similarity with holotricin-2 and also shows sequence homology with coleoptericin A and coleoptericin B.
The Rhinocerosin gene is expressed strongly in the fat body and the Malpighian tubule, and weakly expressed in hemocytes and midgut. Expression in thye midgut is constitutive, wherease in other locations expression is inducible by bacteria.
Rhinocerosin has strong antibacterial activity against Escherichia coli, Streptococcus pyogenes, Staphylococcus aureus. It is inactive against Pseudomonas aeruginosa.
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