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Ranalexin (FLGGLIKIVPAMICAVTKKC) is an antimicrobial peptide isolated from the skin of the bullfrog, Rana catesbeiana (Clark et al, 1994). The peptide contains a single intramolecular disulfide bond that forms a heptapeptide ring. Ranalexin mRNA is first expressed in frog skin at metamorphosis and continues to be expressed into adulthood.

Ranalexin has been shown to be most active against Gram-positive bacteria (Giacometti et al, 1998, 1999). Ranalexin is active against Candida spp and Cryptosporidium parvum (Giacometti et al, 1999), methicillin-resistant Staphylococcus aureus (Giacometti et al, 2000), and Staphylococcus epidermidis (Giacometti et al, 2000).

Ghiselli et al (2001) have shown that Ranalexin can prevent bacterial growth, endotoxemia, and mortality in rats with septic ... ... ... ... ... Subscribe to continue reading! ... ...


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