RTFC

[Regulator of Thyroid Function and Cancer] This gene, encoded by C14ORF93 [chromosome 14 open reading frame 93] has been identified by Liu C et al (2026) as a susceptibility gene for familial nonmedullary thyroid cancer. RTFC promotes thyroid cancer cell survival under starving conditions, and thyroid cancer cell migration. Some RTFC mutations enhance growth of thyroid cancer cells in a Colony formation assay, and are able to transform normal thyroid cells. Cooper et al (2011) have identified RTFC as a potential antigen associated with the pathogenesis of subtypes of peripheral T-cell lymphomas.

Yu Y et al (2017) have reported that the mouse ortholog, named 4931414P19Rik ... ... ... ...
 
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Entry last modified: May 2023