RASA1

(approved gene symbol) [RAS p21 protein activator] This protein is being referred to also as p120GAP [p120 Ras GTPase-activating protein] or Ras GTPase-activating protein, or GAP [GTPase-activating protein] (Trahey et al, 1988).

RASA1 is a multidomain protein that contains two SH2 domains, one SH3 domain, a PH domain, a protein kinase conserved region 2, a RasGTPase-activating domain (Trahey and McCormick, 1987; Glanzer et al, 2002). RASA1 is a negative regulator of the Ras oncogene signaling pathway, which mediates cellular growth, differentiation, and proliferation from various receptor tyrosine kinases ... ... ... ...
 
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Entry last modified: February 2018