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Papilostatins

Papilostatins are bioactive fragments (see also: cryptides) derived from the PAPLN [Papilin] gene, which encodes a proteoglycan-like sulfated glycoprotein. Papilostatins have been shown to inhibit the proliferation and migration of human umbilical vein endothelial cells in vitro and are therefore thought to possess anti-angiogenic properties in vivo (Karagiannis and Popel, 2008).

Papilostatin-1 [GPWAPCSASCGGGSQSRS] corresponds to residues 391-408 of Papilin (Papilin(391-408)).

Papilostatin-2 [SQWSPCSRTCGGGVSFRER] corresponds to residues 33-51 of Papilin (Papilin(33-51) ... ... ... ... ... Subscribe to continue reading! ... ...

 

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