PZP

(approved gene symbol) [Pregnancy zone protein]; The term PZ protein has been used in some older publications. in databanks this protein is known also as CPAMD6 [C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6]. This secreted protein is a major pregnancy-associated plasma protein found at extremely high levels in late pregnancy plasma (Smithies, 1959; Folkersen et al, 1984; Petersen CM et al, 1990). The protein shows strong homology (70 % sequence identity) to alpha-2-Macroglobulin (Sottrup-Jensen et al, 1984; Devriendt et al, 1989; 1991).

Role as protease inhibitor

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Entry last modified: January 2021