PPBPL1 |
PPC |
very late activation |
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[pre-pro-B-cell growth stimulating factor] PPBSF (55 kDa) has been shown to be a self-assembling heterodimer of IL7 and a cofactor with a molecular mass of 30 kDa. Lai et al (1998; Lai and Goldschneider, 2001; McKenna, 1998) have identified the cofactor as a variant beta-chain of hepatocyte growth factor (HGF), a pleiotropic cytokine homologous to plasminogen that regulates cell growth, motility, and morphogenesis.
The protein selectively stimulates the proliferation and differentiation of pre-pro-B-cells in a murine long-term bone marrow culture. The cells are primed to proliferate in response to monomeric IL7
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