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PBP10

This peptide with the sequence QRLFQVKGRR corresponds to gelsolin(160-169), which contains the phosphatidylinositol-4,5-bisphosphate binding site of gelsolin.

PBP10 interacts selectively with both lipopolysaccharides and lipoteichoic acid and can kill the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa and the Gram-positive bacterium Streptococcus pneumoniae (Bucki et al, 2004).

PBP10 is a cell-permeable peptide that interacts with lipid bilayers and cell membranes (Bucki and Janmey, 2006) and also binds polyphosphoinositide. PBP10 enters cells passively and can affect many eukaryotic cellular functions that are dependent on phosphoinositide signaling, including actin ... ... ... ... ... Subscribe to continue reading! ... ...

 

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