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Opistoporin-1 (GKVWDWIKSTAKKLWNSEPVKELKNTALNAAKNLVAEKIGATPS) and Opistoporin-2 (GKVWDWIKSTAKKLWNSEPVKELKNTALNAAKNFVAEKIGATPS) are pore-forming peptides isolated from the venom of the South-African scorpion Opistophtalmus carinatus. These two alpha-helical, cationic peptides differ by only one amino acid. Opistoporin-1 is very active in inhibiting growth of Gram-negative bacteria and also has antifungal activities. Opistoporin-1 possesses hemolytic activity for erythrocytes (Moerman et al, 2002). Elgar et al (2006) have shown that the peptide induces pore formation in cardiac myocytes.

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