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Oncocin

This peptide, VDKPPYLPRPRPPRRIYNRamide, is a derivative of a native antimicrobial peptide isolated originally from Oncopeltus fasciatus (large milkweed bug). It has been optimized for its activity in vitro against Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa. Oncocin is highly active in vitro and non-toxic to mammalian cells (Knappe et al, 2010). Oncocin Onc72 (VDKPPYLPRPRPPROIYNOamide, where O represents L-ornithine) has been optimized further and is highly active against Gram-negative bacteria in vitro and in vivo, protecting mice in systemic infection models with Escherichia coli ... ... ... ... ... Subscribe to continue reading! ... ...

 

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