NACHT-LRR-PYD-containing protein-14 |
N-ac-PGP |
TNFRSF6 |
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gene symbol nkt. Nackt (German for "nude") is a spontaneous recessive mutation affecting hair growth and T-cell development in a moderately inbred stock of mice (Benavides et al, 1999). Skin lesions are characterized by sparse rough coat, bare patches around the eyes and neck, and a scratching behavior throughout life. These mice show delayed hair follicle morphogenesis and late onset of the first catagen stage. The skin of these mice shows mild epidermal hyperplasia and hyperkeratosis, severe hyperplasia of the sebaceous glands, and structural alterations of hair follicles. Epidermal differentiation
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