Morphiceptin

This peptide has been reported originally as a synthetic tetrapeptide amide fragment (Tyr-Pro-Phe-Proamide; YPFPamide) of milk casein-beta (Chang et al, 1981). Morphiceptin is a potent and specific agonist for mu-opiate receptors. It has potent analgesic and cataleptic activities in rats when administered intracerebroventricularly (Chang et al, 1982; Brantl et al, 1981) and produces bradycardia after intravenous administration (Wei et al, 1980). Morphiceptin is one of the most selective agonists for the mu-opioid receptor.

Morphiceptin is an amino-terminal tetrapeptide fragment of beta-casomorphin-7 and corresponds to amidated beta-casomorphin-4. It may be referred to also as beta-casomorphin(1-4).

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Entry last modified: February 2013