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Misgurin

Misgurin is a strongly basic peptide of 21 amino acids (RQRVDDLSKFSKKGAAARRRK) isolated from the loach (mudfish), Misgurnus anguillicaudatus. Misgurin shows strong antimicrobial activity in vitro against a broad spectrum of microorganisms without significant hemolytic activity and is about 6 times more potent than magainin-2. The peptide causes damage to the cell membrane by a pore-forming mechanism similar to that of magainin-2.

For other proteins/peptides with functions in innate immunity and/or antimicrobial activities see also: Innate immunity and defense peptides Dictionary.

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