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MSI

[Male-specific IDGF] This is a transmembrane signaling molecule (gene: CG32178) with exclusive expression in the testis of Drosophila melanogaster. Expression of MSI in insect cells shows that the protein is localized on the cell surface and exhibits growth factor activity (Matsushita et al, 2000).

The protein is related to IDGF (insect-derived growth factor) isolated from the flesh fly and belongs to a family of growth factors (see: ADGF) with adenosime deaminase activity. The gene has been cloned independently as ADGF-2A (see: ADGF).

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