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MGD-1

[Mytilus galloprovincialis defensin-1]; often referred to as mussel defensin. This peptide of 38 amino acids (GFGCPNNYQCHRHCKSIPGRCGGYCGGWHRLRCTCYRC) belongs to the family of defensins. The peptide contains 8 cysteine residues (all of which are involved in disulfide bonding) (Yang et al, 2000), a modified hydroxylated tryptophan residue in position 28, and is processed from a longer precursor expressed in hemocytes (Mitta et al, 1999; Hubert et al, 1996).

MGD-1 has been isolated from the hemolymph of the Mediterranean mussel Mytilus galloprovincialis immunized by injection with bacteria. The peptide is active against Gram-positive bacteria and Gram-negative bacteria but it is not cytotoxic for ... ... ... ...
 
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Entry last modified: November 2006



 
 
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