MAM6 |
Mam-A |
Velcade |
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[Microbial Anti-inflammatory Molecule] MAM is a 15 kDa protein produced by Faecalibacterium prausnitzii (Quévrain E et al, 2016), a bacterium that accounts for 3-5 % of total bacteria in human feces. Decreased gut levels of Faecalibacterium prausnitzii can result in reduced capacity of self-defense against inflammatory reactions. Sokol et al (2008) have reported that the loss of Faecalibacterium prausnitzii is predictive of Crohn's Disease relapse after surgery. Faecalibacterium prausnitzii and its supernatant show protective effects in various chemically-induced colitis models in mice (Sokol et al, 2008; Martín et al, 2014, 2015). Quévrain et al, 2016) have reported that MAM has anti-inflammatory properties in vivo in a DNBS-induced colitis model.
Breyner et al (2017) have reported that MAM protects
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