MADDAM

[metalloprotease and disintegrin dendritic antigen marker] MADDAM is a member of the ADAM family and is the human homolog of murine ADAM19 (meltrin-beta).

The gene encoding MADDAM has been identified by Fritsche et al (2000), who observed its upregulated expression monocytes treated with 1-alpha,25-dihydroxyvitamin D3. Long-term cell culture abrogates expression. Expression of MADDAM is maintained in monocytes differentiated along the dendritic cell pathway. Expression is induced also in CD34(+) derived dendritic cells and Fritsche et al (2003) have suggested that MADDAM is a suitable marker for ... ... ... ...
 
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Entry last modified: December 2004