Lyt10
Lyt10 [Lymphocyte translocation chromosome 10] has been identified during the characterisation of chromosomal translocations (Neri et al, 1991). It shows homology to transcription factor NF-kappa-B and is identical with NFKB2 (see: NF-kappa-B). Lyt10 has been reported to be involved in a chromosomal translocation t(10;14)(q24;q32) in one case of B-cell lymphoma and in gene rearrangements in various types of lymphoid malignancies (Neri et al, 1991; Migliazza A et al, 1994). The rearranged protein retains its ability to bind to NF-kappa-B target sequences, is likely to be constitutively active, and might function as an oncogene.
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