LSC |
LSCKRGTCHFGRCPSHLIKGSCSGG |
prion protein(106-126) |
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[lung squamous cell carcinoma-derived immunosuppressive factor] This biochemically uncharacterized factor of approximately 22 kDa is produced by the lung squamous carcinoma cell line QG56. LSCF is a tumor-derived immunosuppressive factor that inhibits proliferation, cytotoxicity, and expression of cytokine mRNA of T-cells in a dose-dependent manner.
The activity of the LSCF is not blocked by antibodies directed against TGF-beta, and LSCF does not suppress the proliferation of TGF-beta-sensitive mink lung cells (Mv1Lu).
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