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LRIG1

[leucine-rich repeats and immunoglobulin-like domains 1; leucine-rich immunoglobulin-like repeats-1] abbr. also: LIG1. The human gene encoding this transmembrane glycoprotein has been cloned by Nilsson et al (2001) who suggested that it might function as a growth and tumor suppressor.

Gur G et al (2004) have reported upregulation of LRIG1 expression upon EGF stimulation and physical association of LRIG1 with the four EGFR orthologs (erbB1, erbB2, erbB3, erbB4. Upregulation of LRIG1 is followed by enhanced ubiquitylation and degradation of the EGF receptor ... ... ... ... ... Subscribe to continue reading! ... ...

 

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