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LPIN

This cell-penetrating peptide, RRKRRRRRK, corresponds to LPIN3(141-149) (Lim S et al, 2012). It is part of the nuclear localization sequence of LPIN3 [Lipin 3], a human phosphatidate phosphatase, which has phosphatidate phosphatase type-1 activity and has a key role in glycerolipid metabolism (Donkor et al, 2007). A fusion peptide consisting of LPIN linked to enhanced green fluorescence protein delivers the cargo protein efficiently into cells where it localizes to the nucleus as well as the cytoplasm. The peptide penetrates the cell membrane by lipid raft-mediated endocytosis by binding to heparan sulfate proteoglycan. The fusion peptide has been delivered successfully into primary ... ... ... ... ... Subscribe to continue reading! ... ...

 

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