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[latent membrane protein 2A] LMP2A is encoded in the genome of EBV [Epstein-Barr virus latent membrane protein 2A]. It differs from a related protein, LMP2B, only in the first exon (Longnecker, 2000).

LMP2A is a hydrophobic membrane protein found on the plasma membrane and intracellular domains (Longnecker et al, 1991, 1993; Lynch et al, 2002). The protein plays a key role in regulating viral latency and EBV pathogenesis but is not essential for B-cell transformation (Longnecker et al, 1993; Longnecker, 2000).

The N-terminus of LMP2A contains an immunoreceptor tyrosine based activation motif is essential for blocking BCR-mediated signal transduction (Fruehling and Longnecker,1997). A similar motif ... ... ... ... ... Subscribe to continue reading! ... ...


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