LCM factor |
LCN |
Adherence-promoting factor |
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[Lung Cancer Metastasis Related protein 1] This gene has been identified by Chen et al (2011). Sato et al (2003) have identified LCMR1 independently as a critical subunit of the Mediator multiprotein complex, which plays an important role in the elaborate regulation of gene transcription, performing the role of a coactivator required for the activation of RNA polymerase II transcription by DNA binding transactivators. The subunit is being referred to also as MED19 [Mediator complex subunit 19]. Reddy et al (1997) have identified MED19/LCMR1 independently (called DT2P1G7 by them) as a gene containing a CAG repeat.
Xu et al (2012) have reported that LCMR1 suppresses apoptosis in lung cancer cells. Knock-down
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