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L-VEGF

[large VEGF] a high mol weight intracellular isoform of VEGF generated by an alternative translation initiation process. L-VEGF isoforms contain an additional 180 amino acids due to translational initiation at a CUG codon situated in the 5′ untranslated domain of VEGF mRNA (Huez et al, 2001; Bornes et al, 2004; Meiron et al, 2001; Rosenbaum-Dekel et al, 2005). L-VEGF is 206 amino acids longer than the classical AUG-initiated form. L-VEGF is present in different mouse tissues. L-VEGF is cleaved into an intracellular 23 kDa aminoterminal fragment and a secreted fragment with an apparent size similar to that of the classical AUG-initiated form.

The term L-VEGF144 refers to an L-VEGF splice variant that retains the correct exon 6a, exon 7, and ... ... ... ... ... Subscribe to continue reading! ... ...

 

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