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KOP

[Kunitz domain-containing protein overexpressed in pancreatic cancer] The gene encoding KOP has been cloned from pancreatic cancer cell lines (Müller-Pillasch et al, 1998). It is expressed at higher levels in pancreatic cancers and cell lines than in normal pancreatic tissues or chronic pancreatitis tissues.

Sequence analysis shows that KOP is identical with HAI-2, an inhibitor of activators of HGF. The approved gene designation is SPINT2 [serine peptidase inhibitor Kunitz type 2]

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