IREM1

[immune receptor expressed on myeloid cells 1] The gene encoding this protein has been cloned by Alvarez-Errico et al (2004). Three IREM1 splice variants have been reported The 290 amino acid variant lacks exons 2 and 5. The 293 amino acid IREM1 variant lacks exons 1 and 5. Both proteins are type 1 transmembrane proteins. The 165 amino acid variant lacks exons 1, 5, 6, and 7 and has no transmembrane domain. The 194 amino acid variant lacks exon 1 and has no transmembrane domain. Expression has been observed in monocytes and granulocytes, but not in T-cells and NK-cells. Alvarez-Errico et al (2004) have proposed that IREM1 functions to contain ... ... ... ...
 
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