IMP

[inflammation modulatory protein] This protein is encoded by cowpox virus and other pathogenic poxviruses including variola virus (Shchelkunov et al, 1998). It is a highly conserved functional homolog of vaccinia virus complement control protein (VCP) (Miller et al, 1997).

IMP modulates the complement-activated inflammatory response in vivo. Injection of cowpox virus lacking IMP into the footpads of mice causes greater and longer-lasting tissue damage with more hemorrhage than wild-type cowpox virus (Miller et al, 1997; Kotwal et al, 1998).

It is thought that IMP preserves the tissue at the site of infection and promotes evasion of host defense mechanisms (Howard et al, 1998). Infection with virus lacking IMP causes a significant mononuclear cell ... ... ... ...
 
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Entry last modified: January 2002