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ICP22

[infected cell protein 22; infected cell polypeptide 22] (Herpes simplex virus ICP22) This protein of 420 amino acids is encoded by the alpha22 gene of HSV-1 (Herpes simplex virus alpha22 protein). The gene overlaps with the US1.5 gene and is located at the left terminus of the unique short sequence (US) of Herpes simplex virus 1 (Ogle and Roizman, 1999; Post and Roizman, 1987; Watson et al, 1981). The US1.5 protein is expressed from a shorter mRNA and consists of approximately 60 % of the carboxyl-terminal amino acid sequence of the ICP22 (Carter and Roizman, 1996). The shared portion of the gene products is required for efficient viral replication in rodent and rabbit ... ... ... ... ... Subscribe to continue reading! ... ...

 

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