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ICP10PK

This protein is encoded by open reading frame UL39 in the genome of Herpes simplex virus type 2 (Herpes simplex virus type 2 UL39 protein). The encoded protein is the large subunit of a viral ribonucleotide reductase [Herpes simplex virus type 2 R1 protein kinase; Herpes simplex virus type 2 ribonucleotide reductase; Herpes simplex virus type 2 ribonucleoside-diphosphate reductase]. Unlike the mammalian enzyme, which is under stringent allosteric control, the viral enzyme is insensitive to dTTP or dATP inhibition and does not have an absolute requirement for magnesium ions (Langelier and Buttin, 1981). ICP10 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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