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IBD1

[inflammatory bowel disease 1] This is a previous gene symbol used for the NOD2 protein (the approved gene symbol), which is known also as CARD15. A databank designation is NLRC2 [NLR family, CARD domain containing 2].

Inflammatory bowel disease, which is characterized by a chronic relapsing intestinal inflammation is a general term for the clinical entities known as Crohn disease and ulcerative colitis. These diseases are considered to be autoimmune diseases and a predisposition to these diseases have been associated with mutations in the NOD2 (CARD15) protein (Quaglietta et al, 2007).

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