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Hp1404

Hp1404 (GILGKLWEGVKSIFamide) is an antimicrobial peptide with strong sequence relationship to Pantinin-1 and has been identified from the scorpion Heterometrus petersii. The peptide has a specific inhibitory activity against Gram-positive bacteria including methicillin-resistant Staphylococcus aureus. Hp1404 can penetrate the membrane of Staphylococcus aureus at low concentration, and disrupts the cellular membrane directly at very high concentration. Staphylococcus aureus does not develop drug resistance after multiple treatments with Hp1404. Hp1404 shows low toxicity for both mammalian cells and Balb-c mice and can improve the survival rate of the MRSA infected Balb-c mice in a peritonitis model. ... ... ... ... ... Subscribe to continue reading! ... ...

 

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