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HbB(1-10)

[Hemoglobin-beta(1-10)] This peptide, VHLSAEEKEA (Val-His-Leu-Ser-Ala-Glu-Glu-Lys-Glu-Ala) (Schally et al, 1971), derived from porcine hemoglobin-beta, has been isolated from porcine hypothalamus. The peptide depletes the pituitary growth hormone content in rats and stimulates the release of growth hormone in vitro (Schally et al, 1969; Mittler et al, 1970). The peptide also induces the extrusion of growth hormone containing granules from pituitary somatotrophs (Couch et al, 1969).

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