HOP-26

HOP-26 is a monoclonal antibody raised against human marrow stromal fibroblastic cell cultures, known to be rich in progenitors for the stromal lineages (Joyner et al, 1997). The antibody strongly reacts with osteoprogenitor cells in marrow stromal colonies at early stages of differentiation, before the induction of alkaline phosphatase activity. Expression decreases dramatically after the cells reached confluence. In sections of human fetal limb, HOP-26 binds to cells in close proximity to the developing bone, in periosteum, and between the developing bone trabeculae. In adult trabecular bone tissue, HOP-26 is reactive with occasional cells ... ... ... ...
 
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