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HEL-75

The human HEL-75 gene encodes a 95 amino acid protein with a predicted N-terminal signal peptide of 22 amino acids that belongs to the family of Beta-Defensins (Lin et al, 2008). The sequence is identical with DEFB32 [defensin-beta-32; Beta-Defensin-32].

HEL-75 is expressed in the epididymis and lung. The protein is found only in the epididymis. HEL-75 protein binds spermatozoa in the epididymis. Recombinant HEL-75 protein can kill Escherichia coli in vitro in a dose- and time-dependent fashion. It has no effect on sperm motility or fertilization.

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