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HEK293

(also 293 cells) A permanent line derived from primary human embryonal kidney transformed by sheared human adenovirus type 5 (Ad 5) DNA. The cells are hypotriploid and form tumors in nude mice (Graham et al, 1977). HEK293 cells express an unusual heterodimeric cell surface receptor for vitronectin, composed of the integrin-beta-1 subunit and the vitronectin receptor integrin-alpha-V subunit. This receptor appears to mediate cell adhesion exclusively to vitronectin, in contrast to previously described receptors, which have multiple ligands (Bodary and McLean, 1990). Von Laue et al (2000) have shown that HEK293 ... ... ... ... ... Subscribe to continue reading! ... ...

 

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