HBBM |
HBc147-183 |
immortalized cells |
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[HBV core protein; hepatitis B virus core protein] HBc is a protein of 21 kDa encoded in the genome of Hepatitis B virus. The protein, which contains a capsid assembly domain at the N-terminus (residue 1-149) and an arginine-rich domain (ARD) at the C-terminus (residues 150-183) (Birnbaum and Nassal, 1990; Nassal, 1992), is essential for viral replication (Hirsch et al, 1990). The arginine-rich domain is required for pregenome encapsidation and productive viral positive-strand DNA synthesis but not for virus assembly. It also contains signals for nuclear export and import of HBc core protein and particles (Li et al, 2010).
Based on some sequence similarity between the arginine-rich domain and known antimicrobial peptides
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