Fumagalone |
Fumarranol |
Kinase responsive to stress-1 |
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This antibiotic is obtained from Aspergillus fumigatus Fresenius, In vitro, this compound inhibits the growth on endothelial cells.
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The original compound and several derivatives have been synthesized chemically (Corey and Snider, 1972; Ingber et al, 1990; Marui et al, 1992; Marui and Kishimoto, 1992). A derivative, O-[Chloroacetylcarbamoyl]-Fumagillol, known as AGM-1470 or TNP-470, shows the same activity at 50-fold reduced concentrations (Kusaka et al, 1991). Fumagalone is a fumagillin analog in which the spiroepoxide group is replaced with an aldehyde.
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