Fumagillin
This antibiotic is obtained from Aspergillus fumigatus Fresenius, In vitro, this compound inhibits the growth on endothelial cells.
The original compound and several derivatives have been synthesized chemically (Corey and Snider, 1972; Ingber et al, 1990; Marui et al, 1992; Marui and Kishimoto, 1992). A derivative, O-[Chloroacetylcarbamoyl]-Fumagillol, known as AGM-1470 or TNP-470, shows the same activity at 50-fold reduced concentrations (Kusaka et al, 1991). Fumagalone is a fumagillin analog in which the spiroepoxide group is replaced with an aldehyde.
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