FhHDM-1

[Fasciola hepatica helminth defence molecule 1] FhHDM-1 is a peptide secreted by Fasciola hepatica. It is related to the antimicrobial peptide LL-37 with respect to biochemical and functional characteristics (Robinson et al, 2011). FhHDM-1 can be processed by Fasciola hepatica cathepsin L1 to yield a bioactive C-terminal fragment of 34 residues. This is analogous to the proteolytic processing of the cathelicidin CAP-18 to release LL-37, which modulates innate cell activation by classical Toll-like receptor ligands such as lipopolysaccharide (LPS). Recombinant FhHDM-1 and a peptide analogue of the amphipathic C-terminus bind directly to ... ... ... ...
 
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Entry last modified: August 2011