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FREG

also: (FREG-48-58). This peptide, DPHIKLQLQAE, is derived from the fibroblast growth factor bFGF (FGF2) and corresponds to bFGF(48-58) [FGF2(48-58)] (Facchiano A et al, 2003). The peptide is a potent inhibitor of bFGF that acts as a decoy for bFGF. It binds bFGF and interferes with bFGF dimerization, heparin binding, receptor binding, receptor phosphorylation, and bFGF cell internalization, leading to a strong inhibition of most in vitro and in vivo actions of bFGF. The peptide specifically inhibits proliferation and migration of primary ... ... ... ... ... Subscribe to continue reading! ... ...

 

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