FRCs |
FREG-48-58 |
Scg-PVK-3 |
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also: (FREG-48-58). This peptide, DPHIKLQLQAE, is derived from the fibroblast growth factor bFGF (FGF2) and corresponds to bFGF(48-58) [FGF2(48-58)] (Facchiano A et al, 2003). The peptide is a potent inhibitor of bFGF that acts as a decoy for bFGF. It binds bFGF and interferes with bFGF dimerization, heparin binding, receptor binding, receptor phosphorylation, and bFGF cell internalization, leading to a strong inhibition of most in vitro and in vivo actions of bFGF. The peptide specifically inhibits proliferation and migration of primary
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