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Etanercept

[Enbrel] a dimeric fusion protein (943 amino acids; 150 kDa) consisting of the ligand-binding portion of the human 75 kDa TNF-alpha receptor linked to the Fc portion of human IgG1 (see also: antibody fusion proteins) (Pugsley, 2001). The recombinant protein is obtained from CHO cells. The drug is used for the treatment of various inflammatory conditions including rheumatoid arthritis, psoriasis (for overviews see: Berard and Laxer, 2013; Dore, 2014; Kivelevitch et al, 2014; Murdava et al, 2014; Scott, 2014; Strohal et al, 2013). Wadhwa et al (2017) have reported on the results of an international collaborative study to establish a WHO international standard for etanercept.

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